Table 3.
Clinical trial concerning investigations on extracellular vesicles for the diagnosis, prognosis or treatment of colorectal cancer.
| Type, Origin of Exosomes | Official Title of the Study | Biological, Clinical Parameters | Type of Cancer | Type | Clinical Trials.Gov Identifier |
|---|---|---|---|---|---|
| Exosomes from peripheral venous blood drawn immediately prior to surgery | A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors | Diagnosis of colon cancer, prognosis of spreading to other organs | Colon | Observational | NCT03432806 |
| Exosomes from blood sample | Identification of New Diagnostic Protein Markers for Colorectal Cancer | Number, size and protein composition of blood exosomes; diagnosis of colorectal cancer | Colorectal | Observational | NCT04394572 |
| Exosomes from serum samples of patients before, during and after chemoradiation therapy | Exosomes in Rectal Cancer | Exosomal biomarkers assessment; exosomal expression; functional evaluation of exosomes in malignant colonic organoids and mouse models of colorectal cancer | Rectal | Observational | NCT03874559 |
| Exosome RNA from peripheral blood samples before chemoradiotherapy | Study on Predictive Biomarkers of Neoadjuvant Chemoradiotherapy for Rectal Cancer | Biomarkers for response and toxicity to neoadjuvant therapy; treatment optimization | Rectal | Observational | NCT04227886 |
| Protein content and tumor DNA in extracellular vesicles from blood of patients before during and after chemoradiation therapy | A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for Neoadjuvant Treatment Response Assessment in Rectal Cancer | Biomarkers of the response of rectum cancer to neoadjuvant treatment | Rectal | Observational | NCT04852653 |
| Exosomes from stored blood samples of patients diagnosed with colorectal cancer between 2008 and 2012 | Contents of Circulating Extracellular Vesicles: Biomarkers in Colorectal Cancer Patients (ExoColon) | Prognosis value of size, number and content (protein, lipid, RNA…) of circulating exosomes | Colorectal | Observational | NCT04523389 |
| Exosomes from serum samples of patients following psychological intervention | Impact of Group Psychological Interventions on Extracellular Vesicles in People Who Had Cancer (MindGAP-P) | Impact of psychological intervention on the blood concentration of extracellular vesicles and patient outcome | Breast, colorectal cancer | Observational | NCT04298398 |
| Levels of the cytokines IL-6, IL-8, IL-10 and IL-12 in microparticles and serum | The Relationship Between Relaxation or Wheat Germ Juice to the Immune Indices and Quality of Life (QoL) in Colorectal Cancer Patients on Adjuvant Chemotherapy | Impact of physical and psychological well-being on proinflammatory cytokine levels in patients with colorectal cancer | Colorectal cancer stage II or III treated with adjuvant chemotherapy (capecitabine or FU-5 treatment, conjoined with oxaliplatin or capecitabine alone following curative surgery) | Observational | NCT01991080 |
| Blood microparticles | Microparticles in Peritoneal Carcinomatosis of Colorectal Origin | Characterization of microparticulate signature from the blood of patients with peritoneal carcinomatosis of colorectal origin; comparison with colorectal cancer without peritoneal carcinomatosis | Colorectal cancer patient with or without peritoneal carcinosis | Clinical trial, early diagnosis of peritoneal carcinomatosis of colorectal cancer | NCT03969784 |
| Changes of PD-L1 expression on exosomes in peripheral blood after treatment of patients with toripalimab | Phase II Study of Toripalimab Plus Stereotactic Body Radiotherapy in Colorectal Cancer Patients with Oligometastasis | Response to immunotherapy (immune checkpoint inhibition) | Metastatic colorectal cancer | Clinical trial, phase 2 | NCT03927898 |
| Exosomes from serum samples of patients before, during and after radiotherapy | Early Biomarkers of Tumor Response in High Dose Hypofractionated Radiotherapy Word Package 3: Immune Response | Biomarker of immune response | Liver metastasis from colorectal cancer, hepatocarcinoma | Clinical trial | NCT02439008 |
| Exosomes from serum samples of patients during treatment | Tyrosine Kinase Inhibitor (TKI) + Anti-PD-1 Antibody in TKI-responded Microsatellite Stability/Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Adenocarcinoma | Safety of tyrosine kinase inhibitor in combination with anti-PD-1 antibody in TKI-responded MSS metastatic colorectal adenocarcinoma | Metastatic colorectal cancer | Clinical trial, phase 2 | NCT04483219 |
| Measurement of tissue factor-bearing microparticles (tumor origin) | Enoxaparin Thromboprophylaxis in Cancer Patients with Elevated Tissue Factor Bearing Microparticles (MicroTEC) | Evaluation of the efficiency of enoxaparin in preventing blood clots in the veins in participants who have cancer and also have high levels of tissue factor bearing microparticles in their blood | Metastatic colorectal, pancreas, nonsmall cell lung, ovary, gastric | Clinical trial, observation, prevention | NCT00908960 |
| Blood microparticles | Cancer Associated Thrombosis and Isoquercetin (CATIQ) | Efficiency of isoquercetin to prevent venous thromboembolic events in cancer patients | Colorectal (stage IV), pancreas, nonsmall cell lung cancer | Clinical trial, phase II/III, prevention | NCT02195232 |
| Curcumin conjugated with plant exosomes | Study investigating the ability of plant exosomes to deliver curcumin to normal and colon cancer tissue | Impact on immune modulation, cellular metabolism, and phospholipid profile; normal and malignant colon cells from who are undergoing surgery for newly diagnosed colon cancer | Colon | Clinical trial, phase 1 | NCT01294072 |
| Cell-derived exosomes loaded with a synthetic lipid-tagged STAT6 antisense oligonucleotide | A Study of exoASO-STAT6 (CDK-004) in Patients with Advanced Hepatocellular Carcinoma (HCC) and Patients with Liver Metastases from Primary Gastric Cancer and Colorectal Cancer (CRC) | Reprogramming of immune suppressive M2 macrophage to proinflammatory M1 phenotype with potential for meaningful antitumor activity | Liver metastases from gastric and colorectal cancer, hepatocarcinoma | Clinical trial, phase 1 | NCT05375604 |