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. 2023 Feb 10;15(4):1150. doi: 10.3390/cancers15041150

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RBPs and bladder cancer. Various RBPs promote bladder cancer progression by promoting bladder cancer proliferation, e.g., HuR can stabilize HOTAIR mRNA; or promoting bladder cancer proliferation and inhibiting apoptosis, invasion, metastasis, e.g., LIN28A/LIN28B; or promoting angiogenesis, e.g., QKI promotes cancer-related fibroblasts to secrete MFAP5, the main component of elastic fibers, to recruit new blood vessels; or activating EMT in bladder cancer. There remain some RBPs that can inhibit clinical progression of bladder cancer by cell cycle blockage, e.g., RBM3 silenced can increase the number of G2/M stage cells and eventually lead to apoptosis or modulation of cell proliferation and invasion. This figure was made using Figdraw.