Table 1.
The hnRNP family presented by their structural and functional characteristics, and its interacting lncRNAs.
| hnRNP- | Molecular Weight (kDa) | RBD | Binding Sequence | Functions | References |
|---|---|---|---|---|---|
| A1 | 34 | 2 of RRM, RGG box, Gly-enrich domain |
UAGGGA/U | Splicing Translational regulation Influence of mRNA stability |
[111,116,118] |
| A2/B1 | 36/38 | 2 of RRM, RGG box, Gly-enrich domain |
UUAGGG | Splicing Influence of mRNA stability |
[124,125,129] |
| C1/C2 | 41/43 | RRM | Poly U | Splicing Translational regulation Transcriptional regulation |
[111,113] |
| D | 44~48 | 2 of RRM | AU-rich domain | Translational regulation Telomere maintenance |
[113] |
| E | 39 | 3 of KH | Poly C | Splicing Translational regulation Transcriptional regulation Influence of mRNA stability |
[119] |
| F | 53 | 3 of quasi -RRM 2 of Gly-enrich domain |
UUAGG | Splicing Telomere maintenance |
[131,132] |
| K | 62 | 3 of KH | Poly C | Splicing Translational regulation Transcriptional regulation Influence of mRNA stability |
[117,133,134,135] |
| L | 68 | 4 of RRM, Gly-enrich domain |
CA-repeat sequence | Splicing Influence of mRNA stability |
[127,136] |
| M | 77 | 3 of RRM | Poly G/C | Splicing | [121] |
| R | 31 | 3 of RRM, RGG box |
UCUAUC | Translational regulation Transcriptional regulation |
[113] |
| U | 120 | RGG, Gly-enrich domain |
GGACUGCR-RUCGC | Splicing Transcriptional regulation |
[115] |