Figure 1.

Molecular features of immune infiltrated or immune excluded dMMR/MSI-H CRC. Immune infiltrated tumors are characterized by increased PD-L1 and CTLA-4 expression as well as elevated neoantigen presentation. Immune excluded tumors feature a TGF-beta enriched tumor microenvironment with abundant immunosuppressive myeloid cells and fibroblasts. Arrow in blue box means increased. dMMR: deficient mismatch repair. MSI-H: high microsatellite instability. PD-L1: programmed death ligand 1. CTLA-4: cytotoxic T-lymphocyte antigen. MHC I: major histocompatibility complex 1. TIGIT: T cell immunoglobulin and ITIM domain. TMB: tumor mutational burden. CMS1: consensus molecular subtype 1.