Table 1.
The genes that are transcriptional targets of AR [29] found to be downregulated upon VNPP433-3β treatment as revealed by RNA sequencing. All genes except NKX3-1 play crucial role in tumorigenesis.
| Gene | LFC | −Log (FDR) | Remarks |
|---|---|---|---|
| KLK3 | −3.549878878 | 63.74105 | Prostate specific antigen (PSA) |
| KLK1 | −1.499349751 | 24.47005 | Serine protease; Oncoprotein |
| KLK13 | −3.661495531 | 2.685301 | Serine protease; Oncoprotein |
| NKX3-1 | −2.987220702 | 106.1704 | Transcription factor in prostate epithelium, tumor suppressor |
| DHCR24 | −1.242758268 | 17.15381 | Flavin adenine dinucleotide-dependent oxidoreductase; cholesterol biosynthesis |
| DBI | −1.340163994 | 11.44401 | acyl-CoA binding protein, cell signaling, steroid synthesis |
| MMP16 | −1.264127518 | 22.95686 | Cancer metastasis, matrix metalloproteinase |
| FKBP5 | −2.367045284 | 86.07973 | Co-chaperone that regulates steroid hormone receptors, immunoregulation |
| ALDH1A3 | −3.05609345 | 8.603198 | Tumorigenesis, detoxification of aldehydes and lipid peroxidation |
| BCHE | −2.590390622 | 95.29679 | Nonspecific cholinesterase |
| ABHD2 | −1.915809808 | 57.9697 | Enables nuclear steroid receptor activity, highly expressed in spermatozoa |
| SORD | −1.673855387 | 25.39808 | Carbohydrate metabolism |
| ABCC4 | −1.351567948 | 7.512045 | Multidrug resistance, regulates intracellular yclic nucleotide levels, cAMP-dependent signaling to the nucleus |
| BARD1 | −1.850384403 | 30.88807 | DNA repair, E3 ubiquitin ligase, transcriptional regulation to maintain genomic stability |
| TMPRSS2 | −1.160624783 | 9.802972 | Transmembrane Serine Protease 2, upregulated by androgenic hormones in prostate cancer, facilitates virus entry |
| FN1 | −1.795774135 | 45.01869 | Component of extracellular matrix, upregulated in multiple cancers |
| MYC | −2.129324177 | 59.28253 | Oncoprotein |