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The Aryl Hydrocarbon Receptor (AhR) pathway. When inactive, the AhR is located in the cytoplasm and forms a complex with XAP2, also known as AIP, two HSP90 molecules, and p23. After ligand interaction, AhR translocates to the nucleus, interacting with ARNT to create a heterodimer. The heterodimer binds to the XRE and coregulators, leading to the transcription of target genes. AhR crosstalk with the Wnt pathway is also displayed. Figure created with Biorender.com.
