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A diagram of how the binding of CDK4/6 relates to cell cycle progression. RAS signaling and estrogen receptor (ER) activation lead to the production of cyclin D. The binding of Cyclin D to CDK4/6 helps push the cell cycle from the G1 to S phase via Rb phosphorylation. The nodes at which current therapies target the pathway are included as well. Created with BioRender.com.
