Table 4.

Univariate and Multivariate Cox Hazard Ratio Analysis Identifying Characteristics Associated with Death.

Variable	Univariate Analysis: Hazard Ratio (95% CI)	Multivariate Analysis: Adjusted Hazard Ratio (95% CI)
Age Category
Age < 60 years	Reference	Reference
Age ≥ 60 years	4.78 (4.64–4.92)	3.79 (3.68–3.89)
Sex
Female	Reference	Reference
Male	1.74 (1.70–1.78)	1.32 (1.27–1.38)
Anatomic Region
Trunk	Reference	Reference
Head and Neck	1.90 (1.85–1.96)	1.30 (1.27–1.37)
Upper Extremity/Shoulder	1.06 (1.03–1.10)	0.97 (0.92–1.03)
Lower Extremity/Hip	0.86 (0.82–0.89)	0.88 (0.82–0.94)
AJCC Overall Stage
I	Reference	Reference
II	3.88 (3.77–4.00)	1.27 (1.15–1.39)
III	4.82 (4.65–4.99)	2.67 (2.42–2.95)
IV	22.45 (21.42–23.53)	6.00 (5.34–6.76)
Surgical Management
None	Reference	Reference
Local Tumor Excision	0.54 (0.51–0.57)	0.60 (0.53–0.68)
Gross Excision < 1 mm	0.32 (0.30–0.33)	0.38 (0.34–0.42)
Gross Excision > 1 mm	0.41 (0.40–0.43)	0.40 (0.36–0.45)
Surgery NOS	0.95 (0.82–1.10)	0.51 (0.29–0.91)
SLNB
None	Reference	Reference
Yes	1.03 (1.00–1.06)	0.55 (0.52–0.58)
Mitoses
None	Reference	Reference
Yes	3.09 (2.91–3.27)	1.29 (1.20–1.40)
Ulceration
None	Reference	Reference
Yes	4.14 (4.03–4.24)	1.81 (1.71–1.91)
Breslow’s Depth
0.0–1.00 mm	Reference	Reference
1.01 0 2.00 mm	1.95 (1.88–2.02)	1.81 (1.63–1.94)
2.01–4.00 mm	3.93 (3.81–4.07)	2.33 (2.11–2.57)
>4.0 mm	7.36 (7.13–7.61)	3.19 (2.89–3.52)
Histological Type
Superficial Spreading Melanoma	Reference	Reference
Lentigo Maligna Melanoma	2.25 (2.14–2.36)	1.26 (1.15–1.37)
Nodular Melanoma	4.15 (4.01–4.30)	1.20 (1.13–1.29)
Malignant Melanoma NOS	1.52 (1.39–1.66)	1.06 (1.01–1.12)
Desmoplastic Melanoma, Malignant	1.14 (0.29–4.57)	0.96 (0.84–1.11)
Spindle Cell Melanoma	1.76 (1.61–1.91)	0.94 (0.83–1.08)

Abbreviations: SLNB, Sentinel Lymph Node Biopsy.