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. 2023 Feb 9;15(4):1127. doi: 10.3390/cancers15041127

Figure 4.

Figure 4

Chemotherapy reduced tumor growth but induce CTCs in vivo. (A) Mice treated with L-Dox at a dose of 5 mg/kg once/week for 3 weeks (red arrows indicate L-Dox administration) showed a significant suppression of tumor growth and tumor weight. Data are presented as mean + SEM, N = 6. p-value was calculated with a two-sided unpaired Student’s t test. (B) CTCs were captured and identified in both groups of mice. Scale bar, 40 μm. (C) Table listing the levels of CTCs detected in mice treated with L-Dox or PBS. Statistical analysis was performed based on the grading score system according to the CTC count of each mouse (score 1: 0 CTCs; score 2: 0–10 CTCs; score 3: 10–100 CTCs; score 4: >100 CTCs) using a two-sided unpaired Student’s t test, showing significant differences between the L-Dox and PBS groups; p = 0.0079. (D) CTC numeration for each mouse in the L-Dox- and PBS-treated groups.