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Mebendazole decreases the induction of HIF-1α, HIF-2α, and HIF-1β under hypoxic conditions. (A–C) HIF-1α, HIF-2α, and HIF-1β protein expression was analyzed with an immunoblot assay using lysate extracted from MDA-MB-231 (A), SUM159 (B), and MCF-7 (C) cells treated with increasing doses of MBZ as indicated. See Supplementary S1 for uncropped blots for this figure.
