Figure 1.

Pedigree of family #777.Three-generation pedigree with affected individuals represented by black-filled symbols. The subject number is beneath the symbol. Subject #1 is the proband. Beneath the subject number are the numbered alleles for the polymorphic markers. The number of each allele was assigned to the base pair size of the allele. The base pair sizes of the alleles are available by request. The allele of the affected haplotypes that segregate with the disease in family #777 are in red type and highlighted in yellow. At the lower right side of the image is individual #765-8051. This affected individual is from the original NCMD family #765l; beneath #765-8051 is the haplotype of this original NCMD family. Note the affected haplotype in family #777 is different than the affected haplotype in the original NCMD family (#765), suggesting that the 2 families do not share a common founder. The order of the markers is centromere to D6S501, D6S249, D6S1716, NU23, NU20, D6S1717, D6S1565, NU27-GA, NU27-TTT, NU31, D6S1671, D6S475, and D6S283 to telomere. The D6S. . . numbers are polymorphic markers in the MCDR1 locus that are publicly available. The markers noted with “NU. . .” are proprietary markers developed in the authors’ laboratory and are available by request.

Abbreviation: NCMD, North Carolina macular dystrophy.