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PPAR signaling pathway. Upon activation of PPARs and ligands, a heterodimer with RXR is formed, which binds to the PPRE upstream of the target gene promoter, hence regulating the transcription of target genes responsible for energy production, lipid metabolism, cellular functions, and inflammation. Co-activators influence the functioning of many regulators and affect gene transcription. Created with BioRender.com, accessed on 27 December 2022.
