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. 2023 Feb 19;15(4):1319. doi: 10.3390/cancers15041319

Figure 6.

Figure 6

SRF is transcriptional factor that activates IDO1. (A) Promoter sequence of IDO1 and sequences of WT or mut binding sites. Predicted binding sites are marked in red. (B) Dual luciferase reporter assay on cells co-transfected with WT plasmids or plasmids with mut-binding sites and SRF cDNA. (C) SRF binding to the IDO1 promoter was detected using ChIP assays. ** p < 0.01 vs. control. ChIP, chromatin immunoprecipitation; IDO1, indoleamine 2,3-dioxygenase 1; mut, mutated; OSCC, oral squamous cell carcinoma; SRF, serum response factor; WT, wild-type.