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. 2023 Feb 12;15(4):1177. doi: 10.3390/cancers15041177

Figure 1.

Figure 1

XPO1 transports NPM1mut to cytoplasm resulting in A. Homeobox (HOX) overexpression; B. Centrosome duplication; C. defective DNA repair resulting in leukemogenesis; 1. XPO1 inhibitors: inhibits XPO1 mediated cytoplasmic export of NPM1mut; 2. ATRA/ ATO: oxidative injury and apoptosis of NPM1mut cells; 3. Menin inhibitors: suppresses HOX by inhibiting menin- KMT2A complex; 4. CAR-T cell: targets NPM1mut-HLA2 complex, CD133. XPO1- exportin 1; ATRA/ATO- all-trans retinoic acid/arsenic trioxide. (Figure created using BioRender).