Table 3.
(a) A list of statistically significant features identified from two-sided independent Mann–Whitney U test for 3-month treatment response assessment. (b) A list of statistically significant features identified from two-sided independent Mann–Whitney U test for 6-month treatment response assessment.
| (a) | |
|---|---|
| Features | p-Value |
| PVP radiomic features | |
| First-order feature | |
| Uniformity | 0.048 |
| Second-order feature | |
| GLCM_Sum Entropy | 0.040 |
| DeltaP radiomic features | |
| First-order feature | |
| Entropy | 0.045 |
| Uniformity | 0.029 |
| Second-order feature | |
| GLCM_Difference Variance | 0.011 |
| GLCM_Joint Energy | 0.040 |
| GLCM_Joint Entropy | 0.037 |
| GLCM_Sum Entropy | 0.033 |
| GLRLM_Gray-Level Non-Uniformity | 0.031 |
| GLRLM_Gray-Level Non-Uniformity Normalized | 0.037 |
| GLRLM_Run Entropy | 0.010 |
| GLSZM_Gray-Level Non-Uniformity Normalized | 0.010 |
| GLSZM_Size Zone Non-Uniformity Normalized | 0.003 |
| GLSZM_Small Area Emphasis | 0.003 |
| GLDM_Dependence Entropy | 0.029 |
| GLDM_Gray-Level Non-Uniformity | 0.019 |
| NGTDM_Contrast | 0.029 |
| (b) | |
| Features | p-Value |
| Shape and size features | |
| Major Axis Length | 0.018 |
| Maximum 3D Diameter | 0.049 |
| AP radiomic features | |
| First-order feature | |
| Kurtosis | 0.008 |
| Maximum | 0.017 |
| Uniformity | 0.040 |
| Second-order feature | |
| GLCM_Auto-correlation | 0.004 |
| GLCM_Joint Average | 0.004 |
| GLRLM_Gray-Level Non-Uniformity | 0.049 |
| GLRLM_Gray-Level Non-Uniformity Normalized | 0.046 |
| GLRLM_High Gray-Level Run Emphasis | 0.004 |
| GLRLM_Long Run High Gray-Level Emphasis | 0.021 |
| GLRLM_Short Run High Gray-Level Emphasis | 0.004 |
| GLSZM_Gray-Level Non-Uniformity | 0.049 |
| GLSZM_High Gray-Level Zone Emphasis | 0.005 |
| GLSZM_Small Area High Gray-Level Emphasis | 0.005 |
| GLDM_High Gray-Level Emphasis | 0.004 |
| GLDM_Small Dependence High Gray-Level Emphasis | 0.021 |
| NGTDM_Coarseness | 0.049 |
| PVP radiomic features | |
| Second-order feature | |
| GLSZM_High Gray-Level Zone Emphasis | 0.046 |
| DeltaP radiomic features | |
| First-order feature | |
| Entropy | 0.012 |
| Maximum | 0.024 |
| Median | 0.049 |
| Minimum | 0.014 |
| Range | 0.038 |
| Uniformity | 0.030 |
| Second-order feature | |
| GLCM_Joint Entropy | 0.030 |
| GLCM_Sum Entropy | 0.013 |
| GLRLM_Gray-Level Non-Uniformity | 0.026 |
| GLRLM_Gray-Level Non-Uniformity Normalized | 0.030 |
| GLRLM_Run Entropy | 0.009 |
| GLSZM_Gray-Level Non-Uniformity Normalized | 0.002 |
| GLDM_Gray-Level Non-Uniformity | 0.002 |
| NGTDM_Contrast | 0.010 |
| Dosimetric features | |
| V35Gy Percentage | 0.035 |