Figure 1.

Plasma concentrations of atovaquone during treatment. (A) Schema of Induction 1 treatment period including administration of chemotherapy and sampling times. (B) Age distribution of patients included in the clinical trial. (C) Overview of plasma concentrations (μM) in the peripheral blood for each of the 24 patients (grouped by age range based on (B) after starting atovaquone administration. Concentrations were measured on days 11, 13, 15, 18, 20, 22, and at the end of induction (EOI). (D) Maximum peripheral blood plasma concentrations (μM) achieved for each patient. (E) Whisker plot showing the ranges and averages atovaquone peripheral blood plasma concentrations achieved within each age group. X indicates mean concentration; top and bottom vertical lines indicate maximum and minimum values, respectively; top horizontal line of the box indicates 3rd quartile, bottom horizontal line indicates 1st quartile.