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Efficacy of CXCR4 inhibition added to RT in nude mice bearing orthotopic human C4-2B PCa xenografts. (a,b) Tumor volume (a) and the fraction of mice with LN metastasis (b) 28 days after radiotherapy (RT) at a single dose of 12 Gy and/or the initiation of 2-week AMD3100 (AMD) treatment. (c,d) The long-term effects of combination therapy on primary tumor volume (c) and LN metastasis (d), in the same model, at day 60. * p < 0.05; **** p < 0.0001.
