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. 2023 Feb 6;15(4):1021. doi: 10.3390/cancers15041021

Figure 4.

Figure 4

Therapeutic efficacy of post-radiation inhibition of CXCR4 signaling in C57Bl/6 x FVB F1 chimeric mice bearing syngeneic PtenSmad4-null PCa implanted in the tibia (mPCa model). (a) The dynamics of leg thickness (including tumor) following radiotherapy (RT) at a single dose of 12 Gy and/or the initiation of a 2-week AMD3100 (AMD) treatment, compared to control. (b) Kaplan–Meier survival distributions in the four treatment groups. * p < 0.05.