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. 2023 Feb 6;15(4):1021. doi: 10.3390/cancers15041021

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of CXCR4 inhibition with AMD3100 on phenotype of MSCs and their vessel stabilizing action in vitro. (a) Increased expression of pericyte marker NG2 following incubation of MSCs under hypoxic (1% O₂) but not air conditions. (b–d) Increased co-localization of MSCs with endothelial cells in HUVEC-SMC co-culture after incubation with AMD3100 (b). Representative fluorescence microscopy of co-cultures in the control (c) and AMD-treated (d) groups. Arrows show the perivascular MSCs. In blue, DAPI counterstaining; in red, CD31; and in green, NG2. **** p < 0.0001.