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. 2023 Feb 13;12(4):611. doi: 10.3390/cells12040611

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Erastin-induced ferroptosis of MRC5-SV40 cells is inhibited by SkQ1, MitoTEMPO, and methylene blue. MRC5-SV40 cells were treated with erastin (Erast, 10 μM) for 24 h. viability was analyzed using CellTiterBlue^® test. (a) Deferoxamine (DFO, 100 μM), α-tocopherol (α-toc, 10 μM), ferrostatn-1 (Ferr-1, 25 μM), FCCP (5 μM), piericidine (Pier, 1 μM), antimycin A (AntA, 2 μM), MitoTEMPO (10 μM), and methylene blue (MB, 250 nM) were added together with erastin. (b) SkQ1 (10-(6′-plastoquinonyl) decyltriphenylphosphonium bromide) and C₁₂TPP (dodecyltriphenylphosphonium bromide) were added together with erastin. **- p < 0.001.