53BP1	TP53-binding protein 1
5-FU	5-fluorouracil
AKT	RAC-alpha serine/threonine-protein kinase
APC	Antigen-presenting cell
APAF-1	Apoptotic protease-activating factor 1
ATM	Serine-protein kinases ataxia telangiectasia mutated
ATRIP	ATR-interacting protein
BAD	Bcl2-associated agonist of cell death
BAP31	B-cell receptor-associated protein 31
BER	Base excision repair
BRAF	Serine/threonine-protein kinase B-raf
BRCA1/2	Breast cancer type 1 susceptibility protein 1/2
CDC25A/C	M-phase inducer phosphatases
CDK	Cyclin-dependent kinase
cGAS	Cyclic GMP-AMP synthase
CHK1/2	Serine/threonine-protein kinase CHK1/2
CK2	Casein kinase II
COX2	Cyclooxygenase-2
CRT	Calreticulin
CSC	Cancer stem cells
CtIP	CtBP-interacting protein
DAMPS	Damage-associated molecular pattern molecules
DCs	Dendritic cells
DDR	DNA damage response
DISC	Death-inducing signaling complex
DNA-PKcs	DNA-dependent protein kinase catalytic subunit
DSBR	Double-strand break repair
DSBs	Double-strand breaks
ED	Extracellular domain
eIF2α	Eukaryotic translation initiation factor 2A
EMT	Epithelial-to-mesenchymal transition
ERK	Extracellular signal-regulated kinase
ES-SCLC	Extensive-stage small cell lung cancer
EXO1	Exonuclease 1
FA	Fanconi anemia
FADD	FAS-associated death domain protein
FdUMP	5-fluoro-2′-deoxyuridine 5′-monophosphate
FdUTP	Fluorodeoxyuridine triphosphate
FLIP	Flice-like inhibitory protein
FOXO1	Forkhead box protein O1
GADD45	45kd-growth arrest and DNA damage
GDSM	Gasdermin
GZMA/B	Granzyme A/B
HIF-1α	Hypoxia-inducible factor alpha
HMG1/2	Nonhistone chromosomal high-mobility group 1 and 2
HMGB1	High mobility group protein 1
HR	Homologous recombination
hUBF	Highly similar to Human upstream binding factor
ICD	Immunogenic cell death
ICLs	Interstrand crosslinks
ICT	Intracellular cytoplasmic tail
IFN	Interferon
IL	Interleukin
ILC2s	Group 2 innate lymphoid cells
irAEs	Immune-related adverse effects
IRF	Interferon regulatory factor
ITIM	Immunoreceptor tyrosine-based inhibitory motif
ITSM	Immunoreceptor tyrosine-based switch motif
JAK	Tyrosine-protein kinase
JNK	Jun amino-terminal kinase
KU70/80	X-ray repair cross-complementing protein 5/6
M2	Tumor-associated macrophages M2
mAbs	Monoclonal antibodies
MCM2/7	Minichromosome maintenance complex
MDC-1	Mediator of DNA damage checkpoint protein 1
MDM2	Mouse double minute 2 homolog
MDSC	Myeloid-derived suppressor cells
MDSCs	Myeloid-derived suppressor cells
MEK	Dual specificity mitogen-activated protein kinase kinase
MHC	Major histocompatibility complex
MLH1	DNA mismatch repair protein MLH1
MMR	Mismatch repair
mPGES1	Prostaglandin E synthase
MRE11	Double-strand break repair protein MRE11
MSH2/6	DNA mismatch repair protein MSH2/6
MSI	Microsatellite instability
mtDNA	Mitochondrial DNA
mTOR	Serine/threonine-protein kinase mTOR
Nal-IRI	Liposomal irinotecan
NBS1	Nibrin
nDNA	Nuclear DNA
NER	Nucleotide excision repair
NF-Kβ	Nuclear factor NF-kappa-B p105 subunit
NHEJ	Non-homologous end joining
NK	Natural killer cells
OMI	Serine protease HTRA2
OS	Overall survival
P2RX7	P2X purinoceptor 7
PAR	Polymer ADP-ribose residues
PARP-1	Poly [ADP-ribose] polymerase 1
PARPi	PARP inhibitor
PD-1/PD-L1	Programmed death receptor-1/programmed death ligand-1
PERK	Eukaryotic translation initiation factor 2-alpha kinase 3
PFN	Perforins
PFS	Progression-free survival
PGE2	Prostaglandin E2
PI3K	Phosphatidylinositol-4,5-bisphosphate 3-kinase
PKC	Protein kinase C
PLCg-1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
PLK	Serine/threonine-protein kinase PLK
PRR	Pattern recognition receptors
PS	Phosphatidylserine
PTEN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase
RAD50	DNA repair protein RAD50
RAD51	DNA repair protein RAD51 homolog 1
RAD52	DNA repair protein RAD52 homolog
RAP80	Receptor-associated protein 80
RNF4, -8, -168	E3 ubiquitin-protein ligases
ROS	Reactive oxygen species
RPA	Replication protein A
SCLC	Small-cell lung cancer
SHP1/2	Src homology region 2 domain containing phosphatases
SMACK	Diablo IAP-binding mitochondrial protein
SSBR	Single-strand break repair
ssDNA	Single-stranded DNA
STAT	Signal transducer and activator of transcription
STING	Stimulator of interferon genes protein
TBP	TATA binding protein
TCR	T-cell receptor
TGF-β	Transforming growth factor β
TICs	Tumor-initiating cells
TILs	Tumor infiltrating lymphocytes
TLR	Toll-like receptor
TLS	Translesion DNA synthesis
TM	Transmembrane domain
TMB	Tumor mutational burden
TNF-α	Tumor necrosis factor α
TOPBP1	Topoisomerase 2-binding protein 1
TP53	Cellular tumor antigen p53
Tregs	Regulatory T cells
WAF1/CIP1	Cyclin-dependent kinase inhibitor 1
XLF	Non-homologous end-joining factor 1
XRCC4	X-ray repair cross-complementing protein 4