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. 2023 Feb 9;12(4):556. doi: 10.3390/cells12040556

Figure 4.

Figure 4

Monoclonal antibodies against E2 protein inhibit iCHIKV and rE2 protein-induced mechanical hyperalgesia. mAb1 (A,D), mAb2 (B,E), and mAb3 (C,F) (1 or 5 µg, 5 µL) were co-injected (intra-articular) with rE2 (100 ng, 5 µL, A–C), or iCHIKV (100 FFU, 5 µL, D–F) or Mock (control, 10 µL). The mechanical hyperalgesia was evaluated 1–7 h after injection and daily for seven days. Results are presented as mean ± SEM of six mice per group per experiment and are representative of two independent experiments. * p < 0.05 compared to Mock group; # p < 0.05 compared to rE2 group. ANOVA followed by Tukey’s test.