Table 1.
List of approved immunotherapies for lymphoma.
| Drug Name | Class | Main Action | Treatment Protocol | Approved for |
|---|---|---|---|---|
| Rituximab | mAb 1 | CD-20 Antibody | With chemotherapy | First line for NHL 2 |
| Brentuximab Vedotin | mAb 1 | CD-30 Antibody | With chemotherapy | Advanced HL 3 |
| Nivolumab | ICI 4 | PD-1 Blockade | Standalone | cHL 5 |
| Pembrolizumab | ICI 4 | PD-1 Blockade | Standalone | Refractory cHL 5 |
| Tisagenlecleuce | CAR-T 6 | T-lymphocyte-mediated CD-19 expression | Standalone | Adult R/R DLBCL 7 |
| Lisocabtagenel maraleuecel |
CAR-T 6 | T-lymphocyte-mediated CD-19 expression | Standalone | R/R large B-cell lymphoma |
| Mosunetuzumab | BiTes 7 | Follicular Lymphoma | Standalone | R/R Follicular Lymphoma |
1 mAb: Monoclonal Antibody; 2 NHL: Non-Hodgkin’s Lymphoma; 3 HL: Hodgkin’s Lymphoma, 4 ICI: Immune Checkpoint Inhibitor; 5 cHL: Classical Hodgkin’s Lymphoma; 6 CAR-T: Chimeric Antigen Receptor Therapy; 7 BiTes: bispecific T-cell engagers.