Skip to main content
. 2023 Feb 17;15(4):1288. doi: 10.3390/cancers15041288

Table 5.

Univariable and multivariable logistic regression model to identify covariates associated with late CTCAE gastrointestinal toxicity after CRT.

Covariates Level CTCAE Grade 2+ GI Late Toxicity (6–24 Months) CTCAE Grade 2+ GI Persistent GI Late Toxicity
No
(n=377)		 Yes
(n=52)		 Univariable Multivariable
(n = 428)		 No
(n=415)		 Yes
(n=18)		 Univariable
N (%) or
Median
(IQR)		 N (%) or
Median (IQR)		 OR (95% CI) p
value		 OR (95% CI)
p
value		 N (%) or
Median (IQR)		 N (%) or
Median (IQR)		 OR (95% CI) p
value
Baseline grade 2+ GI toxicity
No
Yes
Missing		 373 (99)
2 (1)
2		 49 (98)
1 (2)
2		 308 (99)
3 (1)
4		 18 (100)
0 (0)
0
Baseline EPIC-26 bowel
sub-domain score		 Median
(n)		 100
(96-100)
(n=339)		 100
(92-100)
(n=46)		 0.99 (0.95-1.02) 0.55 100
(96-100)
(n=373)		 96
(92-100)
(n=16)		 0.98 (0.93-1.04) 0.55
Worst acute grade 2+
GI Toxicity		 No
Yes
Missing		 352 (94)
24 (6)
1		 40 (77)
12 (23)
0		 4.4 (2.04-9.47) <0.0001 4.61
(2.11-10.06)		 <0.0001 379 (92)
33 (8)
3		 15 (83)
3 (17)
0		 2.30 (0.63-8.34) 0.21
Persistent grade 2+ acute GI
toxicity		 No
Yes		 374 (99)
3 (1)		 48 (92)
4 (8)		 10.39 (2.26-47.82) 0.003 409 (99)
6 (1)		 17 (94)
1 (6)		 4.01
(0.46-35.19)		 0.21
Worst acute EPIC-26 bowel
sub-domain score		 Median
(n)		 92 (75-100)
(n=354)		 88 (67-96)
(n=51)		 0.98 (0.97-1.00) 0.04 92 (75-100)
(n=390)		 87.5 (67-92)
(n=17)		 0.97 (0.95-1.00) 0.02
Worst acute
bowel symptoms

Grade 1+ rectal bleeding

Grade 2+
diarrhoea

Grade 1+ rectal pain

Grade 2+
proctitis


No
Yes

No
Yes

No
Yes

No
Yes


319 (85)
57 (15)

395 (100)
0 (0)

333 (89)
43 (11)

368 (98)
8 (2)


39 (75)
13 (25)

30 (83)
6 (17)

39 (75)
13 (25)

49 (94)
3 (6)


1.87 (0.94-3.71)


3.72 (0.66-20.83)


2.58 (1.28-5.22)


2.82 (0.72-10.97)


0.08


0.14


0.008


0.14


347 (84)
65 (16)

406 (99)
6 (1)

357 (87)
55 (13)

401 (97)
11 (3)


13 (72)
5 (28)

18 (100)
0

17 (94)
1 (6)

18 (100)
0


2.05 (0.71-5.96)





0.38 (0.05-2.93)





0.19





0.35
Age Median
(n)		 69 (65-73)
(n=377)		 69 (66-73.5)
(n=52)		 1.01 (0.96-1.05) 0.80 69 (65-73)
(n=415)		 70 (67-75)
(n=18)		 1.04 (0.96-1.12) 0.37
Prostate Volume (cm3) Median
(n)		 44 (33-58)
(n=367)		 43 (32-55)
(n=47)		 0.99 (0.98-1.01) 0.50 44 (33-58)
(n=401)		 38 (30-46)
(n=15)		 0.98 (0.95-1.02) 0.32
Risk group
(intermediate)		 low
int		 42 (11)
335 (89)		 1 (2)
51 (98)		 6.39 (0.86-47.48) 0.07 6.32 (0.83-48.2) 0.08 43 (10)
372(89)		 0
18 (100)
Fiducial use (Yes) No
Yes		 158 (42)
219 (58)		 27 (52)
25 (48)		 0.67 (0.37-1.19) 0.17 0.74 (0.41-1.35) 0.33 181 (44)
234 (56)		 6 (33)
12(67)		 1.55 (0.57-4.20) 0.39

OR = odds ratio; IQR = interquartile range; GI = gastrointestinal; EPIC = Expanded Prostate Cancer Index Composite; Int = Intermediate. Multivariable analysis for CTCAE grade 2+ persistent late GI toxicity was noted performed due to low number of events.