Table 2.
Bootstrapped C-indices. The top performing pipelines for each statistical model (namely CPH, LASSO Cox, Boosted Cox, and RSF) are highlighted in bold.
| Model | C-Index | 95% Confidence Interval |
|---|---|---|
| Memorial Sloan Kettering (MSKCC) | 0.770 | (0.675, 0.844) |
| Clinical Variables Only | ||
| Cox | 0.798 | (0.724, 0.857) |
| LASSO | 0.761 | (0.710, 0.824) |
| Boosted | 0.770 | (0.709, 0.829) |
| RSF | 0.795 | (0.727, 0.852) |
| Clinical Variable and Correlation Prefiltered mRNA variables | ||
| Cox | 0.828 | (0.720, 0.909) |
| LASSO | 0.762 | (0.696, 0.826) |
| Boosted | 0.816 | (0.757, 0.866) |
| RSF | 0.749 | (0.695, 0.811) |
| Clinical Variables and Univariate Cox Feature Selected mRNA variables | ||
| Cox | 0.765 | (0.688, 0.827) |
| LASSO | 0.768 | (0.703, 0.835) |
| Boosted | 0.798 | (0.737, 0.845) |
| RSF | 0.782 | (0.730, 0.846) |
| Clinical Variables and Correlation Prefiltered and Univariate Cox Feature Selected mRNA variables | ||
| Cox | 0.792 | (0.671, 0.865) |
| LASSO | 0.763 | (0.464, 0.918) |
| Boosted | 0.814 | (0.753, 0.863) |
| RSF | 0.821 | (0.747, 0.874) |