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Airway epithelia regulating epi-immune response upon allergen/pathogen exposure. Pathogens or allergens disrupt the airway epithelia. Disrupted epithelia releases alarmins (IL-25, IL-33, and TSLP). Alarmins activate dendritic cells for Th2 polarization of the immune response. On the other hand, alarmins can directly activate ILC2 cells to secret IL-4, IL-5, and IL-13 cytokines. The dysregulation of this pathway leads to asthma pathogenicity.
