Table 1.

Key study characteristics studies included for synthesis.

Author	Year	Study Design	Country	Center	Span	Number of GBM Patients	Total Sample Size	Study Aim	Reported Outcomes
Damato et al. [19]	2021	Retrospective cohort	USA	Washington University School of Medicine	2010–2018	166	166	Evaluate the timing of adjuvant TMZ chronotherapy on GBM patient survival	OS, OS-12
Damato et al. [20]	2022	Prospective feasibility	USA	Washington University School of Medicine	2016–2020	21	35	Feasibility and clinical impact of TMZ administration in the morning versus evening	OS, compliance, clinical and hematologic adverse effects, QoL