Table 3.

Predictive models for outcome.

	OR	95% CI	p-Value	AUC	95% CI	p-Value
All XAI populations				0.95	0.91–0.98	<0.0001
CLL-IPI				0.78	0.70–0.86	<0.0001
Four-factor model				0.84	0.77–0.91	<0.0001
CLL-IPI	1.53	1.19–2.04	0.0018
T1C0016 (CD4+ T cells)	0.86	0.78–0.93	0.0003
T1C0023 (CD8+ T cells)	1.14	0.95–1.77	0.3305
CD38	1.01	1.00–1.02	0.1790
Two-factor model with IPI				0.83	0.77–0.90	<0.0001
CLL-IPI	1.64	1.29–2.16	0.0001
T1C0016 (CD4+ T cells)	0.85	0.78–0.92	0.0002
Two-factor model w/o IPI				0.79	0.71–0.87	<0.0001
T1C0016 (CD4+ T cells)	0.85	0.78–0.91	<0.0001
T1C0023 (CD8+ T cells)	1.29	1.05–2.14	0.1390

Abbreviations: OR = odds ratio; TTF = time to first-line treatment failure; AUC = area under curve; CI = confidence interval, IPI = International Prognostic Index.