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. 2023 Jan 29;45(2):1073–1085. doi: 10.3390/cimb45020071

Figure 2.

Figure 2

NEAT1 knockdown induces resistance against an AKT-targeted drug, capivasertib. (A) Representative Western blot images for the indicated proteins. GAPDH is shown as an internal control. HLF and HuH6 cell lines were transduced with adenoviruses expressing non-targeting shRNA [shNT (N)] or NEAT1-specific shRNAs [shNEAT1a (Na) and shNEAT1b (Nb)] for 48 h. (B) Viabilities of HLF and HuH6 cells treated with capivasertib at the concentrations indicated in the figure for 48 h relative to cells treated with DMSO (100%). Cells were transduced with adenoviruses expressing shNT, shNEAT1a, and shNEAT1b 48 h before drug treatment. * p < 0.05 vs. shNT vs. shNEAT1a; # p < 0.05 shNT vs. shNEAT1b (Dunnett’s test; n = 4).