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Models for transcription activation by the two activation domains of CREB. (A) A sequential model for CAD activation involves interaction between CAD and the hTAF130 subunit of TFIID to recruit TFIID to the promoter, thereby increasing the rate of formation of the polymerase complex and the overall rate of transcription (12, 13). (B) An alternative model involves bivalent recruitment of TFIID by CAD and holoenzyme by P-KID interaction with CBP and RNA helicase A (41, 42).
