Table 2.
Follow-up of clinical studies of preterm infants stabilized with higher vs. lower initial FiO2 in the delivery room.
| Study Design | [Initial FiO2] | Objectives | Neurodevelopmental Evaluation Test | Outcomes | |
|---|---|---|---|---|---|
| Boronat [56] | RCT GA ≤ 32 weeks Pulseoximetry Target SPO2 n = 206 |
0.3–0.6 | Outcome at 24 months postmenstrual age (PMA) | Bayley III | No differences |
| Soraisham [54] | Retrospective cohort GA ≤ 28 weeks n = 1509 |
0.21–1.0 | Outcome at 18–21 months PMA | Bayley III | Severe NDI in survivors was significantly higher in the 100% oxygen group |
| Kapadia [55] | Retrospective cohort GA ≤ 28 weeks n = 199 |
0.21–1.0 | Outcome at 22–26 months PMA | Bayley III | No differences |
| Thamrin [57] | RCT GA < 32 weeks n = 215 |
0.21–1.0 | Death or NDI at 24 months PMA | Bayley III | No differences SpO2 < 80% were more likely to die or to have NDI |
Abbreviations: RCT: Randomized controlled trial; SPO2: Oxygen saturation; GA: Gestational age; PMA: Postmenstrual age; NDI: Neurodevelopmental impairment.