Table 4.
Performance of FAST core cut-off values for detecting at-risk NASH (NASH + NAS ≥ 4 + F ≥ 2) in biopsy-proven NAFLD.
| Rule out at-Risk NASH | Grey Zone | Rule in at-Risk NASH | ||||||
|---|---|---|---|---|---|---|---|---|
| Study | Cut-Off | AUROC | Se/Sp (%) | NPV | Interval | Cut-Off | Se/Sp (%) | PPV |
| Newsome [107], 2020 Derivation (n = 350) |
≤0.35 | 0.8 | 90/53 | 0.85 | 0.35–0.67 | ≥0.67 | 48/90 | 0.83 |
| External Validation (n = 1026) | ≤0.35 | 0.85 | 89/64 | 0.94 | 0.35–0.67 | ≥0.67 | 49/92 | 0.69 |
| Woreta [109], 2022 (n = 585) |
≤0.35 | 0.81 | 91/50 | 0.9 | 0.35–0.67 | ≥0.67 | 52/87 | 0.69 |
| Lee [110], 2022 (n = 251) |
≤0.35 | 0.714 | 93.1/35.2 | 0.926 | 0.35–0.67 | ≥0.67 | 56.9/77.1 | 0.5 |
| De [111], 2022 biopsy-proven NAFLD (n = 60) |
≤0.35 | 0.81 | 91/14 | 0.88 | 0.35–0.67 | ≥0.67 | 73/67 | 0.33 |
| biopsy-proven NASH (n = 17) | ≤ 0.55 | 0.81 | 90/45 | 0.95 | 0.55–0.78 | ≥ 0.78 | 64/94 | 0.7 |
| Cardoso [112], 2022 (n = 287) |
≤0.35 | 0.78 | 78.8/64 | 0.878 | 0.35–0.67 | ≥0.67 | 41.2/89.1 | 0.618 |
AUROC—area under the ROC curve; Se—sensitivity; Sp—specificity; NPV—negative predictive value; PPV—positive predictive value; N/S—not specified; n—population.