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. 2023 Feb 5;12(4):692. doi: 10.3390/foods12040692

Table 1.

Publications showing the results of using probiotics for IBD in animal models.

Ref. Numbers, Model, Age Moulding Method Probiotic Strains CFU/Dose, Duration Effects
[30] 25, Dark Agouti rats, 30 d TNBS L. rhamnosus 64 3 × 106 CFU, daily, 27 d damage score↓, immune cell infiltration↓, cytokine↓, MPO activity↓.
[31] 90, BALB/c mice, 7 w DSS L. rhamnosus 1.0320 2 × 108 CFU, daily, 28 d the DAI score↓, hemoglobin content↑, MPO activity↓, IL-1β↓, IL-6↓, TNF-α↓ and IL-10↑.
[32] 48, Wistar rats, 10 w Acid L. rhamnosus EM1107 109 CFU, daily, 17 d TNF-α↓, myeloperoxidase↓, IL-1β↓and oxidative stress↑. IL-17↓, NF-κB p65↓, MMP-2↓, MMP-9↓, and iNOS↓, SOCs-1↑, ZO-1↑ and mucin-2↑.
[33] 32, C57BL/6J mice, 6 w DSS L. rhamnosus LDTM 7511 109 CFU, daily, 14 d colon length↑, spleen weight↓, Lcn-2↓, MPO↓, CRP↑, relatively intact colonic architecture, Chao1 index↑, Shannon index↑.
[34] 40, C57BL/6 mice, 8 w DSS L. rhamnosus L34 1 × 107 CFU, once every 3 d, 14 d the gut local inflammation↓, gut-leakage severity↓, fecal dysbiosis↓ and systemic inflammation↓.
[35] 40, C57BL/6Cnc mice, 8 w DSS L. rhamnosus SHA113 109 CFU, 9 d SCFA-producing genera↑, UC-related genera↓.
[36] 16, BALB/c mice, 6 w DSS L. rhamnosus OLL2838 107 CFU, 3 d Body weight↑, and colon length↑, expression of zonula occludens-1 and myosin light-chain kinase↑
[37] 40, C57BL/6J mice, 5 w DSS L. rhamnosus Hao9 109 CFU, 7 d DAI↓, colon length↑, alleviated colonic pathological variations, histological scores↓, TNF-α, IL-6, and IL-1β ↓, IL-10↑.
[38] 50, C57BL/6 mice DNBS L. rhamnosus I-3690 5 × 109 CFU, 10 d macroscopic scores↓, cytokine levels↓, colon and ileum MPO activities↓

Damage score: Crude morphological scoring of the isolated colonic tissue [30]. Disease activity index (DAI) score: A composite score combining three conditions: percent weight loss, stool consistency, and stool bleeding [31]. DSS: dextran sulfate sodium salt; TNBS: trinitro-benzene-sulfonic acid; MPO: myeloperoxidase; IL-: interleukin-; TNF-α: tumor necrosis factor-; MMP-: matrix metalloproteinase-; ZO-1: zonula occludens-1; CRP: C-reactive protein; Lcn-2: lipocalin– 2/NGAL;.