[39] |
187 adults |
UC |
LGG |
18 × 109 CFU, 12 m |
LGG treatment is more efficient than standard treatment in extending relapse-free time. |
[40] |
4 children |
CD |
LGG |
1010 CFU, twice a day, 6 m |
The median activity index of children with CD at 4 weeks was 73% lower than at baseline. |
[41] |
11 adults |
CD |
LGG |
2 × 109 CFU, daily, 6 m |
The median time to relapse was on average 4 weeks longer in the LGG group than in the placebo group. |
[42] |
14 children |
CD |
LGG |
1010 CFU, twice a day, 10 d |
Oral administration of LGG increased the intestinal IgA immune response, thus promoting the intestinal immune barrier. |
[43] |
37 adults |
CD |
LGG |
6 × 109 CFU, twice a day, 52 w |
LGG appears to neither prevent one-year endoscopic recurrence nor reduce the severity of recurrent disease. |
[44] |
117 adults |
CD&UC |
LGG |
1.4 × 1010 CFU, daily, 52 w |
Patients taking daily LGG had a lower frequency of first postoperative inflammatory bowel disease complications. |