FIG. 2.

Predicted peptide sequences of the variable domain in naturally occurring het-c alleles. The underlined area is the het-c variable domain that is necessary and sufficient to confer het-c allelic specificity in the N. crassa het-c^OR (FGSC 2489), het-c^PA (FGSC 1130), and het-c^GR (FGSC1945) alleles (39, 40). ∗, conserved sites. Dashes represent deletions. Regions I and II are polymorphic blocks; region III encompasses the indel motif. Each clade is supported by over 94% bootstrap values (48). HET-C^PA-like, HET-C^OR-like, and HET-C^GR-like refers to the indel pattern observed in the genetically characterized N. crassa het-c^PA, het-c^OR and het-c^GR alleles, respectively (39). Clade 4 has representatives in all three HET-C-like classes based on the indel motif; separation of these three het-c types is supported by bootstrap values of less than 94%. GenBank accession numbers for nucleotide sequences of these alleles were previously cited (48); accession numbers are AF092695 to AF092732 and AF093679.