Table 1.

Fluorescein angiography vs. ICGA angiography vs. OCT-A angiography.

Fluorescein Angiography	ICG Angiography	OCT-Angiography
Invasive	Invasive	Non-invasive
Widefield analysis	Widefield analysis	Current technology offers limited field of view in commercially available machines
Kinetic analysis of blood flow and flow of liquids	Kinetic analysis of blood flow and flow of liquids	Static blood vessel imaging (sufficient flow necessary to detect vessels)
Information on the retina (choriocapillaris on the first 40–60 s)	Information on the choroid (some vascular information about the retina)	Information on the retina and choriocapillaris
Side effect from dye (rare)	Side effect from dye (very rare)	No dye needed
Non-repeatable at short interval, ±10 min exam duration	Non-repeatable at short interval, ±30 min exam duration	Repeatable, <5 min capture
Should be avoided in pregnancy or renal dysfunction (or performed with caution)	Should be avoided in pregnancy or hepatic dysfunction (or performed with caution)	No limitations
Information on retinal vascular leakage	Information on choroidal vascular leakage	No information on vascular leakage
Information on active iCNV	Information on active iCNV	Detection of iCNV (distinction between active/non-active not always available)
Dual FA/ICGA ➔ Global information on all inflammatory diseases two-dimensional	Dual FA/ICGA ➔ Global information on all inflammatory diseases two-dimensional	Limited information on limited disease entities three-dimensional

ICG: indocyanine green; OCT: optical coherence tomography; ILM: internal limiting membrane RPE: retinal pigment epithelium; iCNV: inflammatory choroidal neovascularization.