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Structure of the enterovirus genome. The genome contains a single open reading frame that encodes a polyprotein and is flanked by 5′ and 3′ untranslated regions (UTRs). The encoded polyprotein contains three major regions (P1, P2, and P3). These regions can self-digest into four separate structural proteins (VP1, VP2, VP3, and VP4 from P1) and seven nonstructural proteins (2A, 2B, and 2C from P2; 3A, 3B, 3C, and 3D from P3) [5].
