Table 1.
Biallelic goa-1 mutations exhibit a variable degree of developmental phenotypes.
| Genotype | Embryonic Lethality (%) |
Larval Arrest (%) |
Brood Size (% of Controls) |
Pvl Phenotype (%) |
|---|---|---|---|---|
| goa-1[WT] | 0.5 1 | 0 | - | 1 |
| goa-1[R209H] | 5 (p < 0.01) 2 | 5 (p < 0.01) | 80 (p < 0.01) | 10 (p < 0.01) |
| goa-1[E246K] | 21 (p < 0.001) | 40 (p < 0.001) | 18 (p < 0.001) | 50 (p < 0.001) |
1 Twenty hermaphrodites per genotype were assayed to evaluate the brood size. More than 200 animals per genotype were tested in all other assays. 2 p-values are calculated using two-way ANOVA with Bonferroni correction.