Table 3.

Treatment, according to the stage of the disease.

Stage I Stage II

➢UVB-Narrow Band (mainly T1a and T2a) ➢PUVA (thicker plaques) ➢Topical corticosteroids ➢ECP ➢Topical chemotherapy: mechlorethamine, gel (Valchlor), gel (Ledaga®) ➢Systemic chemotherapy with one or more drugs: retinoids, INF-alpha, low-dose methotrexate, TSEB ➢Other drug therapy (lenalidomide, histone deacetylase inhibitors) ➢Targeted therapy: brentuximab vedotin, mogamulizumab

Stage III Stage IV

➢UVB-Narrow Band ➢PUVA (thicker plaques) ➢Topical chemotherapy: mechlorethamine, gel (Valchlor), gel (Ledaga®) ➢ECP ± RI total skin electron beam radiation therapy ➢RT total skin electron beam radiation therapy. ➢Systemic chemotherapy with one or more drugs: retinoids, INF-alpha, low-dose methotrexate, TSEB ➢Other drug therapy (lenalidomide, bexarotene, histone deacetylase inhibitors, pembrolizumab) ➢Targeted therapy: brentuximab vedotin, mogamulizumab ➢High-dose chemotherapy, and sometimes RT, with stem cell transplant.

Psoralen and ultraviolet A (PUVA), extracorporeal photopheresis (ECP), radiation therapy (RT), inteferona (INF), total-skin electron beam therapy (TSEBT).