FIG. 2.

Dynamics-based description of allostery (a) The Cooper–Dryden model postulates that reorganization of internal protein motions allows for allosteric communications in proteins in the absence of any major conformational change. (b) The Elastic Network Model reduces a protein into an elastic mass-and-spring network. Allosteric stimuli (like mutations and ligand binding) alter the mass density and moduli of connecting springs.