FIG. 3.

Violin model of allostery. (a) Harmonic nodes create a vibrational resonance pattern on the plates of a violin called “Chladni patterns.” At different node frequencies, different parts of the plates are synchronized to vibrate together or against each other. Elastic properties of the plate affect Chladni patterns. Chladni pattern pictures obtained from Ref. 62. (b) If the kinase bi-lobal structure is thought of as a violin, Chladni patterns are reflective of the resonance patterns of internal vibrations/amino acid motions of the protein. Different effectors (like binding of PKI and PKS) generate distinct “community maps” when analyzing dynamics-based amino acid networks.