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. 2023 Feb 25;26(4):106274. doi: 10.1016/j.isci.2023.106274

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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A proposed model showing how novel cysteines in NRP1 extracellular domains determine the fate of SARS-CoV-2 virus entry

(Top panel) Intact novel cysteines in NRP1 determine its functional capability by providing the attachment site to SARS-CoV-2 S protein leading toward the internalization of virus in the host cells. (Bottom panel) Alteration to those cysteine residues significantly reduces the binding between viral S protein and NRP1 and blocks the virus entry into the host cells. Figure created with BioRender.com.