Fig. 1.

Structure models of the synthetic complement regulators MFHR1 and MFHR13 predicted by AlphaFold2 (AF2). Structure of MFHR1 top-ranked models (A) and MFHR13 (B). Superimposition of the 5 top-ranked models are shown in the left panel, while the best model is displayed in the right panel with the pLDDT score (0−100) by colours (>90 in blue, high confidence, and<50 in red, low confidence). C. Prediction of MFHR1 (left panel) and MFHR13 (right panel) dimerization interface by AlphaFold-Multimer (AFM). The linker between FHR1 and FH domains is also predicted with different possible conformations. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)