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. 2022 Dec 23;42(9):638–650. doi: 10.1038/s41388-022-02578-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Increased RPL21 mRNA levels correlate with shorter overall survival of human head and neck squamous cell carcinoma (HNSCC) patients. RPL21 top and bottom quartile mRNA expression in TCGA HNSCC patients′ samples (n = 519). Cox regression hazard ratio 1.4629. B Increased RPL21 TOP motif-containing transcripts 201 and 202, but not the TOP-less transcript 203, correlate with shorter overall survival of head and neck squamous cell carcinoma (HNSCC) patients. RPL21 top and bottom quartile transcript expression in TCGA HNSCC patients′ samples (n = 519). The 4 main human RPL21 isoforms are depicted in the upper panel, all isoforms code for the identical 160 amino acid RPL21 protein. Two transcripts contain a classic 5′TOP motif (red), one contains a TOP-like motif (blue) and one transcript does not express a 5′TOP motif. C mRNA expression levels of the differentially spliced translation-related genes in TCGA head and neck squamous cell carcinoma (HNSCC) patients′ samples (n = 519) and non-diseased esophageal tissue (non-diseased pharynx samples were not available). D Alternative splicing events significantly stratify head and neck squamous cell carcinoma patient survival. The alternative splicing events between the two transcripts correlating with survival, RPL21-201 and RPL21-204, and the transcript that did not correlate with survival (RPL21-203) were directly compared in head and neck squamous cell carcinoma patients′ samples (n = 519). The ratio between the alternative splicing events was calculated and the overall survival of the top and bottom quartile alternative splicing events was assessed.