Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 3;42(9):665–678. doi: 10.1038/s41388-022-02588-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — A A representative MEM event with partial cellularization. Following entosis, the two nuclei synchronized in cell cycles. The new PGCC underwent multiple endomitotic events followed by karyokinesis and internal cellularization to generate fecundity cells. Gray: cell membrane, LCK-GFP. Magenta: nuclei, H2B-mCherry. The two initially adherent cells are labeled as c1 (smaller cell) and c2 (host PGCC), and the progeny daughter cells of cell c1 are labeled as c1-a and c1-b (white arrows in panel b). The white arrow in panel h, fecundity cell generated during the first round of MEM; white arrows in panels q and r, fecundity cell generated during the fourth round of MEM; magenta arrow in panel r, chromatin aggregate encapsulated by a plasma membrane pocket. (Bottom panel) Schematic illustration of cell proliferation kinetics. The mitotic phase’s length was defined by the time interval between the start of prophase and the next nuclei re-formation. The time format is hours: minutes: seconds. Z with numbers indicates the z-slice position of the current image. Bar equals 20 μm. B A representative RMEM event was observed under a 2D condition. The spindle assembly indicates restitution mitosis (showing intensive green fluorescence) without complete separation of the condensed chromosomes. a–j Magenta: H2B-mCherry. Green: α-tubulin-GFP. Cyan arrow: giant pleomorphic nucleus; green arrows: dispersed spindle assemblies; white arrow: a micronucleus. (Bottom panel) Schematic illustration of cell proliferation kinetics. The time format is hours: minutes: seconds. Bar equals 20 μm.