Table 3.
Association results of independent genetic variants at chromosome 5 that were peak-wise significantly associated with severe asthma exacerbations in Hispanics/Latinos from GALA II (2006–2014)
| Mexican Americans | Puerto Ricans | Meta-analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
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| rsID | Position (Bp)a | A1/A2 | Closest gene | EAF | OR (95% CI) | p-value | EAF | OR (95% CI) | p-value | OR (95%CI) | p-value |
|
| |||||||||||
| rs1144986 | 147883415 | G/A | C5orf46 | 0.13 | 0.43 (0.28–0.66) | 9.45×10−5 | 0.22 | 0.79 (0.62–1.00) | 4.94×10−2 | 0.60 (0.33–1.08) | 1.61×10−4 b |
| rs7704889 | 147911637 | A/G | C5orf46/EEF1GP2 | 0.54 | 1.58 (1.23–2.03) | 4.00×10−4 | 0.42 | 0.97 (0.79–1.20) | 7.94×10−1 | 1.23 (0.77–1.98) | 6.57×10−3 b |
| rs10035432 | 147855193 | A/G | SCGB3A2/CTC-327F10.1 | 0.26 | 1.61 (1.23–2.11) | 4.82×10−4 | 0.21 | 1.02 (0.81–1.29) | 8.72×10−1 | 1.28 (0.81–2.00) | 5.93×10−3 b |
| rs35439318 | 147862111 | C/T | SCGB3A2/CTC-327F10.1 | 0.15 | 0.51 (0.34–0.74) | 5.26×10−4 | 0.22 | 0.83 (0.65–1.05) | 1.27×10−1 | 0.66 (0.41–1.08) | 1.45×10−3 b |
a
Coordinates are referred to the human reference genome assembly GRCh38
b
A random effect model was applied since heterogeneity was found between populations (Cochran’s Q p-value<0.05). Association p-values<0.05 are shown in bold.
Abbreviations: A1: Effect allele; A2: Non-effect allele; Bp: Base pairs; CI: Confidence interval; EAF: Effect allele frequency; OR: Odds ratio; rsID: reference single nucleotide polymorphism identifier.