Table 2.
Local Ancestry at CYP2C9 and VKORC1
| Gene | Copiesa | Tucson, AZ (n = 141) | San Juan, PR (n = 96) | Total (n = 237) | P-valueb |
|---|---|---|---|---|---|
| CYP2C9 | EUR | < 0.001 | |||
| 0 | 28 (20.3%) | 8 (8.4%) | 36 (15.5%) | ||
| 1 | 55 (39.9%) | 23 (24.2%) | 78 (33.5%) | ||
| 2 | 55 (39.9%) | 64 (67.4%) | 119 (51.1%) | ||
| AMR | < 0.001 | ||||
| 0 | 58 (42.0%) | 87 (91.6%) | 145 (62.2%) | ||
| 1 | 56 (40.6%) | 6 (6.3%) | 62 (26.6%) | ||
| 2 | 24 (17.4%) | 2 (2.1%) | 26 (11.2%) | ||
| AFR | < 0.001 | ||||
| 0 | 131 (94.9%) | 70 (73.7%) | 201 (86.3%) | ||
| 1 | 7 (5.1%) | 21 (22.1%) | 28 (12.0%) | ||
| 2 | 0 (0.0%) | 4 (4.2%) | 4 (1.7%) | ||
| VKORC1 | EUR | < 0.001 | |||
| 0 | 23 (17.3%) | 4 (4.4%) | 27 (12.1%) | ||
| 1 | 54 (40.6%) | 21 (23.1%) | 75 (33.5%) | ||
| 2 | 56 (42.1%) | 66 (72.5%) | 122 (54.5%) | ||
| AMR | < 0.001 | ||||
| 0 | 59 (44.4%) | 88 (96.7%) | 147 (65.6%) | ||
| 1 | 52 (39.1%) | 3 (3.3%) | 55 (24.6%) | ||
| 2 | 22 (16.5%) | 0 (0.0%) | 22 (9.8%) | ||
| AFR | < 0.001 | ||||
| 0 | 129 (97.0%) | 69 (75.8%) | 198 (88.4%) | ||
| 1 | 4 (3.0%) | 18 (19.8%) | 22 (9.8%) | ||
| 2 | 0 (0.0%) | 4 (4.4%) | 4 (1.8%) |
a
Copies indicates the haploid count of ancestrally similar segments at a given gene and copies are denoted for each ancestral reference used
b
Hypotheses were tested with chi-square goodness of fit test for equal counts per cohort with tableby() from the arsenal package in R
AZ indicates Arizona; PR, Puerto Rico; CYP2C9, Cytochrome P450 family 2 subfamily C member 9; VKORC1, Vitamin K epoxide Reductase Complex subunit 1; EUR, Europeans of the Iberian Peninsula and Spain; AMR, Indigenous American (multiple ethnic groups); AFR, Africans of Yorubaland