Table 3.
CYP2D6 star allele frequencies across all sub‐Saharan African populations included in the study
| Allele frequencies (%) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CYP2D6 allele | CPIC function | All (n = 947) | FNB (n = 49) | BRN (n = 49) | BFA (n = 33) | GHA (n = 26) | CAM (n = 26) | BSZ (n = 41) | BOT (n = 47) | SA (n = 153) | ESN (n = 98) | YRI (n = 107) | GWD (n = 111) | MSL (n = 84) | LWK (n = 95) |
| *1 | Normal | 24.7 | 17.3 | 24.5 | 30.3 | 26.9 | 21.2 | 32.9 | 31.9 | 22.9 | 29.6 | 25.7 | 26.6 | 18.5 | 20.5 |
| *2 | Normal | 13.4 | 9.2 | 15.3 | 13.6 | 13.5 | 21.2 | 12.2 | 11.7 | 13.7 | 9.2 | 11.2 | 14 | 14.3 | 18.4 |
| *27 | Normal | 0.3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.1 |
| *34 | Normal | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0 |
| *39 | Normal | 0.1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| *45 | Normal | 3.7 | 4.1 | 3.1 | 4.5 | 7.7 | 3.8 | 3.7 | 2.1 | 4.9 | 4.6 | 3.3 | 1.8 | 3.6 | 3.7 |
| *46 | Normal | 0.5 | 0 | 1 | 0 | 0 | 0 | 0 | 1.1 | 0 | 1 | 0 | 1.4 | 0 | 1.1 |
| *17x2 | Normal | 0.2 | 1 | 0 | 1.5 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0 | 0 | 0 |
| *29x2 | Normal | 0.3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.4 | 0 | 0.5 |
| *10 | Decreased | 3.9 | 5.1 | 3.1 | 1.5 | 0 | 1.9 | 4.9 | 3.2 | 4.6 | 1.5 | 4.7 | 5.4 | 8.9 | 1.1 |
| *17 | Decreased | 19.5 | 30.6 | 23.5 | 15.2 | 21.2 | 5.8 | 14.6 | 19.1 | 16.7 | 22.4 | 22.9 | 14.9 | 23.8 | 18.4 |
| *29 | Decreased | 10.0 | 4.1 | 10.2 | 12.1 | 5.8 | 13.5 | 17.1 | 6.4 | 10.1 | 7.1 | 9.3 | 9.9 | 8.9 | 16.3 |
| *41 | Decreased | 0.8 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0.7 | 1.5 | 0.9 | 0.5 | 0.6 | 2.6 |
| *84 | Decreased | 0.1 | 0 | 1 | 0 | 0 | 0 | 0 | 1.1 | 0 | 0 | 0 | 0 | 0 | 0 |
| *4 | No function | 1.7 | 3.1 | 0 | 0 | 0 | 3.8 | 1.2 | 0 | 2.3 | 2.6 | 0.5 | 2.7 | 1.2 | 2.1 |
| *5 | No function | 8.1 | 7.1 | 6.1 | 6.1 | 7.7 | 7.7 | 7.3 | 13.8 | 14.7 | 3.6 | 6.5 | 5 | 8.9 | 4.7 |
| *12 | No function | 0.2 | 0 | 0 | 0 | 0 | 1.9 | 0 | 2.1 | 0 | 0 | 0 | 0 | 0 | 0 |
| *15 | No function | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.5 | 0 | 0 | 0 |
| *36 | No function | 0.4 | 0 | 0 | 1.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.8 | 1.2 | 0 |
| *40 | No function | 1.4 | 1 | 1 | 0 | 1.9 | 1.9 | 0 | 2.1 | 2.6 | 2.6 | 0.5 | 0.9 | 1.8 | 0 |
| *42 | No function | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0.5 |
| *56 | No function | 0.2 | 0 | 0 | 0 | 0 | 0 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0.6 | 0 |
| *69 | No function | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.3 | 0 | 0 | 0 | 0 | 0 |
| *68 + *4 | No function | 0.1 | 0 | 0 | 0 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| *13 | No function | 0.1 | 0 | 0 | 1.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| *4x2 | No function | 2.2 | 2 | 2 | 3 | 3.8 | 3.8 | 1.2 | 0 | 1.3 | 5.1 | 4.7 | 1.4 | 1.8 | 0.5 |
| *4x3 | No function | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0.6 | 0 |
| *1x2 | Increased | 0.4 | 0 | 1 | 0 | 3.8 | 0 | 0 | 1.1 | 0 | 0 | 0.5 | 1.4 | 0 | 0 |
| *1x3 | Increased | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.7 | 0 | 0.5 | 0 | 0 | 0 |
| *2x2 | Increased | 1.9 | 2 | 3.1 | 3 | 0 | 1.9 | 0 | 3.2 | 0 | 5.1 | 2.8 | 2.3 | 1.2 | 1.1 |
| *2x3 | Increased | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.6 | 0 |
| *2x4 | Increased | 0.1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| *45x2 | Increased | 0.1 | 0 | 0 | 0 | 0 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 |
| *45x3 | Increased | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 |
| *43 | Uncertain | 0.8 | 0 | 2 | 1.5 | 1.9 | 0 | 0 | 0 | 0.3 | 0.5 | 0 | 1.8 | 0 | 3.2 |
| *43x2 | Uncertain | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0 | 0 |
| *73 | Unknown | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| *74 | Unknown | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.3 | 0 | 0 | 0 | 0 | 0 |
| *106 | Unknown | 1.5 | 5.1 | 0 | 3 | 1.9 | 3.8 | 1.2 | 0 | 0.7 | 1 | 3.3 | 1.8 | 1.2 | 0 |
| *122 | Unknown | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0 |
| *125 | Unknown | 0.3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0.5 | 0.5 | 0 | 0.5 |
| *139 | Unknown | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.5 | 0 | 0 | 0 | 0 |
| *149 | Unknown | 0.3 | 0 | 0 | 1.5 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0.9 | 0.6 | 0 |
BFA, participants from Burkina Faso; BOT, participants from Botswana; BRN, Berom in Nigeria; BSZ, Bantu‐speakers in Zambia; CAM, Cameroonian participants; ESN, Esan in Nigeria; FNB, Fon in Benin; GHA, Ghanaian participants; GWD, Gambian in Western Division (Mandinka); LWK, Luhya in Webuye (Kenya); MSL, Mende in Sierra Leone; SA, South African participants; YRI, Yoruba in Ibadan, Nigeria.