Fig. 6.

Correlations of bioactive LMs with tau protein in an age-matched sub-cohort. The levels of lipid mediators (LMs) in cerebrospinal fluid (CSF) samples from the age-matched cohort of patients with Alzheimer’s disease (AD) (n = 15), mild cognitive impairment (MCI) (n = 17), or subjective cognitive impairment (SCI) (n = 21) were correlated to the CSF levels of total tau (t-tau) or phosphorylated tau (p-tau) and the r-value according to Spearman rank-order test is given together with the P-value (see Supplementary Table 4c, d). In the AD group, resolvin (Rv) D1 shows a negative correlation to the p-tau levels and when analyzing all three diagnostic groups together, whereas prostaglandin (PG) D2 levels correlated positively to the levels of p-tau. The levels of the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) correlated negatively to t-tau levels