. Author manuscript; available in PMC: 2024 Feb 14.

Published in final edited form as: Immunity. 2023 Jan 30;56(2):444–458.e5. doi: 10.1016/j.immuni.2023.01.002

Table 1. Gini coefficients for 20 core IBD risk genes in TI and colon.

Functional relevance to IBD from¹².

	Functional relevance in IBD	Gene names	Gini (TI)	Highest mean expression cell type (TI)	Gini (CO)	Highest mean expression cell type (CO)

IL23R	Adaptive immunity, Th17	IL23R	0.84	ILCs	0.85	ILCs
NKX2–3	Restitution	NKX2–3 NKX23 NKX2C	0.81	Endothelial cells CA4⁺ CD36⁺	0.76	Endothelial cells CD36⁺
CARD9	Microbe-sensing	CARD9	0.77	Macrophages PLA2G2D⁺	0.77	DC2 CD1D⁻
EBF1	B cells	EBF1 COE1 EBF	0.72	Pericytes HIGD1B⁺ STEAP4⁺	0.82	Pericytes HIGD1B⁺ STEAP4⁺
IL2RA	Adaptive immunity, Treg	IL2RA	0.70	Macrophages PLA2G2D⁺	0.74	Tregs
NOD2	Microbe-sensing	NOD2 CARD15 IBD1	0.71	Monocytes S100A8⁺ S100A9⁺	0.73	Monocytes S100A8⁺ S100A9⁺
HNF4A	UPR, Healing	HNF4A HNF4 NR2A1 TCF14	0.68	Epithelial cells HBB⁺ HBA⁺	0.75	Enterocytes TMIGD1⁺ MEP1A⁺
PTPN22	Tolerance	PTPN22 PTPN8	0.61	T cells OGT⁺	0.67	T cells OGT⁺
LRRK2	Lysosome function	LRRK2 PARK8	0.59	Neutrophils S100A8⁺ S100A9⁺	0.65	Monocytes S100A8⁺ S100A9⁺
IKZF1	B cells, Treg	IKZF1 IK1 IKAROS LYF1 ZNFN1A1	0.51	T cells OGT⁺	0.61	T cells OGT⁺
SLC22A5	(carnitine transporter)	SLC22A5 OCTN2	0.54	Epithelial cells METTL12⁺ MAFB⁺	0.49	Enterocytes TMIGD1⁺ MEP1A⁺
GPR35	Epithelial barrier	GPR35	0.50	Neutrophils S100A8⁺ S100A9⁺	0.52	Enterocytes TMIGD1⁺ MEP1A⁺
INPP5E	(phosphatase)	INPP5E	0.39	T cells OGT⁺	0.42	Pericytes HIGD1B⁺ STEAP4⁺
PRDM1	B cells, Treg	PRDM1 BLIMP1	0.37	Plasma cells	0.43	Macrophages LYVE1⁺
JAK2	Adaptive immunity, Cytokines	JAK2	0.34	Neutrophils S100A8⁺ S100A9⁺	0.44	Monocytes S100A8⁺ S100A9⁺
SMAD3	Treg	SMAD3 MADH3	0.35	Neutrophils S100A8⁺ S100A9⁺	0.42	T cells OGT⁺
IFIH1	Microbe-sensing	IFIH1 MDA5 RH116	0.29	Neutrophils S100A8⁺ S100A9⁺	0.36	Monocytes S100A8⁺ S100A9⁺
TYK2	Adaptive immunity, Cytokines	TYK2	0.29	Monocytes S100A8⁺ S100A9⁺	0.32	T cells OGT⁺
NFKB1	Immune signaling	NFKB1	0.23	Neutrophils S100A8⁺ S100A9⁺	0.32	Monocytes S100A8⁺ S100A9⁺
EP300	(transcriptional coactivator)	EP300 P300	0.22	Tuft cells	0.31	T cells OGT⁺